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How to Make Penicillin by Yourself

You probably know this, but penicillin is the best known antibiotic in the world. It has a long history of use before the times of modern medicine and is still used in hospitals today. It was officially discovered in 1928 by Alexander Fleming in the UK.

Although it had been used for centuries before this by ancient Greeks, Egyptians and others, they could not identify or separate the compound which cured the disease. In the spring of 1942 the first patient to be treated for septicemia was treated with US made penicillin and this used up 50% of stock available at the time. Just a few years later near the end of the Second World War, the US had to produce 2.3 million doses in preparation for the D-Day landings.

If you were ever stranded in the wild far from civilization and need to make your own penicillin then the following methods can be used.

Disclaimer

The information in this article is provided “as is” and should not be mistaken for or be a substitute for medical advice. While Shane Jackson is a doctor, he is not your doctor, so consult your physician before trying any of the advice presented on this page. Always seek the help of a professional. Neither the author nor www.SurvivalSullivan.com or the company behind the website shall be held liable for any negative effects of you putting into practice the information in this article.

Steps

To make penicillin at home you are going to need equipment, ingredients and time. This is not a quick fix solution that you can make within hours of becoming concerned that you or a loved one have an infection.

You will need to start with a mold culture or starter source. The best way to begin is with old bread or citrus peel. This will be the fuel the mold will use to grow from and you will need to monitor the mold as it matures. Initially as the food becomes stale the surface will start to become grey and fuzzy. This means that the tendrils of the mold are beginning to spread but it is still too early to harvest. Once left for a few days, a more yellow-green fur will become apparent eventually turning a bright bluish green.

Congratulations, you have now produced penicillin from either Penicillium chrysogenum or Penicillium nalgiovense! This of course is not pure or pharmaceutical grade penicillin as you still have your stale food, mold and penicillin all together. In this state it is quite hard to ingest and you will have to consume the whole mix for it to have any effect.

For a purer and easier to eat mixture, it is a good idea to extract the penicillin and store it separately. Now that you have your starter amount, you will need two large flasks, both sterilized by heating in an oven for an hour at 315 degrees.

Break your starter mold and food fuel into small pieces and place inside a flask, then seal and incubate for a week at 70 degrees. Whilst you are waiting for the spores to grow you will need to go and find the following ingredients, alongside a scale that can measure milligrams. You standard kitchen scale definitely won’t do for this!

Penicillin Incubation Solution

Solution base: 500ml cold water

Solid ingredients:

44g      Lactose monohydrate

25g      Cornstarch

3g        Sodium nitrate

0.25g   Magnesium sulfate

0.5g     Potassium monophosphate

2.75g   Glucose monohydrate

0.044g Zinc sulfate

0.044g Manganese sulfate

Penicillin: A step-by-step guide

  1. Pour 500ml of water into a sterile container which can be sealed with a top.
  2. Add the solid ingredients as listed, preferably in powdered form so they dissolve faster.
  3. Add a further 400ml of cold water to this solution once mixed.
  4. Read the level on your flask and top up the fluid level to 1 liter.
  5. It is very important that you now mix the solution properly. Check that the contents have dissolved before you stop stirring.
  6. You will now need to check with some litmus paper that you have the right acidity, or pH. Dip the litmus paper into the solution and check it against the guide supplied with the litmus.
  7. It will likely be too alkaline, ie. a pH greater than 7. Add drops of hydrochloric acid until the litmus paper shows a pH of 5.5 to 6.
  8. Now add your mold to the solution, seal and leave for seven days.
  9. At the end of the incubation period you finally have penicillin! This incubation period will separate the penicillin from the rest of the liquid and leave it floating on top.
  10. At the end of the week, skim off the surface of the mixture using filter paper.
  11. Place the penicillin you have just made into a dry container for storage and future use.

The water from your tap will be at a pH of 6.5 and 8.5 depending on the stone at groundwater level. Using bottled water is usually at more neutral pH of 7. Either way you will need to add hydrochloric acid in small amounts until it reaches a pH of 5.5 to 6. This is crucial as a solution that is too acidic or too alkaline could destroy the penicillin you have made so far.

WARNING

Before you go running off into the sunset and the wild outdoors read the next section very carefully.

Making your own home grown antibiotics without proper training or equipment, and then self-diagnosing and treating without hospital grade investigations and equipment, leaves you with a very high risk of making a mistake or something going wrong.

The instructions you have just read are for emergency, last resort situations. Always choose the safest choice first, like going to a hospital or clinic with trained staff. If you are living without access to transport, communication or the emergency services then treating yourself may be only option. If a trained professional can treat you, then that will always be your best bet.

What have you actually grown?

Unless you have access to individual strains of bacteria, petri dishes and several hundred thousand dollars’ worth of medical equipment, you will never know for sure. By following the steps above you will have produced a good amount of the antibiotic penicillin but you will have also generated other organic compounds.

The mold itself will have produced other chemicals to fight off bacasteria that can be harmful to humans, especially in large amounts. If there has been a mistake in the sterilization process, other molds from your food source or even bacteria resistant to penicillin may have worked their way into your incubation.

Incubating with the solution described will rid the penicillin you harvest of some impurities but again there is no way of testing at home how pure it actually is. These impurities have the potential to harm you more than the penicillin is helping.

What does penicillin treat?

Penicillin is not a cure all! If you have become sick and had to be admitted to hospital, your blood would be taken and then cultured in a lab. Any bacteria found would then be placed in a petri dish with a selection of different antibiotics including penicillin itself. Different antibiotics work in different ways, from breaking down the cell wall to stopping cell reproduction. Penicillin stops bacteria from being able to make or repair their cell wall which means they can’t stop water from flowing inside. This swells the bacteria, eventually bursting and killing them.

Unfortunately this method of killing bacteria makes penicillin a ‘narrow-spectrum’ antibiotic, meaning that it only affects certain types of bacteria, not all. ‘Gram positive’ bacteria are more likely to be affected as they lack an extra membrane around the cell wall that helps to hold the cell together.

Penicillinase?

There is one final piece of the puzzle to consider when using penicillin in the modern world. After many years of use, it was discovered that a number of infections that used to be treated with penicillin were no longer being cured. In the lab scientists found the presence of Penicillinase. The -ase part of the word tells us this is a molecule which breaks down penicillin! In other words the lab had seen that bacteria had mutated to make a chemical which destroys and stops the effects of penicillin. In the modern world we use tonnes of antibiotics every day for everything from treating the sick to ridding livestock of disease.

Remember

None of this is a substitute for real medical advice of any actual situation you may be having in the future. Growing and using your own penicillin is an emergency, last resort procedure. If you are lucky, it could cure an infection or stop one spreading from a wound. If you are less lucky, it might slow the progress of the infection or have no effect at all.

It should be viewed as extra bit of safety which gives you time to seek proper medical advice. Don’t forget there are plenty of infections that can seem like they’re caused by bacteria but are actually a viral infection. This includes very serious, life-threatening infections like viral encephalitis and no antibiotic, no matter how strong, will ever treat them.

Safe and Natural Alternatives

The above may be the solution you need in the most extreme of circumstances but it carries with it a high degree of risk. In a world where safer options are available for less dire situations you may want to look to preventative measures rather than last resort attempts at a cure.

If you are carrying out further research beyond this article, be aware that there is a difference between antiseptics and antibiotics! Antiseptics are superficial only and tend to be wiped over the skin or affected area for a matter of seconds with little to no lasting effect.

Think of it this way. If you fall over into dirty water and cut your hand then washing the cut immediately with antiseptic may kill all the bacteria and clear the wound. There is no guarantee however and if bacteria do enter your bloodstream further application of antiseptic will not affect them at all.

Antibiotics are therefore best in cases where you know there is an infective source (like eating food contaminated with salmonella) or when developing an infection is very likely (coming into contact with a contagious patient).

Antiseptics on the other hand are best used when there has been mild injury or small infection that doesn’t require hospital attention.

A good example to start with is toothache, which can be very aggravating and is usually the sign of gum or tooth disease. Antiseptic is only useful when the tooth pain is sharp and not dull! Dull pain usually indicates that nerves have been damaged and is beyond the scope of antiseptics. Go to your local dentist if you have persistent dull oral pain to get an effective antibiotic.

The antibiotics below are best thought of as preventative measures, rather than cures. If you or a loved one feel very unwell it is always best to seek medical attention if you can.

Oral Treatments

Clove oil

This contains eugenol which numbs the surrounding area, classically applied to a sore tooth. This strong compound with a distinctive smell and taste which carries antiseptic properties.

Salt water

This is a basic idea but always useful. Bacteria are prevented from growing anywhere there is a high salt concentration so this makes a great antiseptic mouthwash.

 

Turmeric

Make this into a paste using the powder and a small amount of water. The curcumin inside turmeric is the active ingredient and has antiseptic, antibacterial and analgesic (pain relief) properties all in one. Mix with manuka honey (see below) for even better results and taste.

Consumable Treatments

Oregano oil

There is a virus called Helicobacter pylori (or H.pylori for short) that your doctor may have mentioned. It infects over two thirds of the world’s population at some point and can lead to stomach ulcers and cancer. Oregano oil has been shown to clear infection in 70% of cases in one study as well as fighting off many other types of bacteria.

 

mustard oil

Mustard oil

Mustard oil holds similar properties to oregano and thyme but as recently as 2016 scientists are beginning to understand that it can be even more potent due to attacking bacteria using multiple mechanisms of action. Keep an eye out for more studies in the future.

 

horseradish plant

Horseradish

This is almost never mentioned as an organic treatment, but new research is showing it may be the most potent of them all. Not only has Horseradish been shown to provide a range of benefits usually only seen when taking numerous treatments at a time. It can clear congested chests, promote your own immune system against cancer and infection all whilst also having antiviral and bacterial properties. If that isn’t enough it also relaxes your muscles at the end of a tough day.

 

acv

ACV

Apple Cider Vinegar seems to have a range of uses, commonly with athletes and the elderly to protect joints and tendons. It has however also shown promise as an antiviral, antibacterial and antifungal all rolled into one. Drink a tablespoon every morning but have a chaser ready to get rid of the taste!

 

garlic

Garlic

This commonly used cooking ingredient contains a natural antibiotic – allicin, and was first used in the 1700s to fend off the plague. It does have an antibiotic effect but it is too weak to be significant in humans. Avoid relying on this one.

 

ginger

Ginger

This is perhaps the most well-known natural antiseptic, perhaps only behind salt. It seems to be better aimed at food borne infections like salmonella. This is why sushi usually comes served with pickled ginger! Before the times of refrigeration in Japan it served as protection against gone off fish.

 

Topical Treatments

 

Honey

Try and get a hold of manuka honey, which has been shown in research to have the best properties in terms of antibacterial action. It can inhibit several drug resistant bacteria and more importantly it attacks biofilms. These are formed by groups of bacteria and are hard to break through, making manuka honey good for wounds or mucosal surfaces like your lips and mouth.

 

Grapefruit

Grape seed extract of grape fruit has been put into petri dishes alongside other standard treatments and a host of bacteria. Even after overnight incubation it has been found comparable to topical antibiotics.

 

Salt Water

Bathing in salt water or applying it to a wound will have antiseptic effects. This is a good, cheap option for cleaning wounds but don’t overdo it. Applying pure salt to a wound may kill any bacteria but it will also heavily damage the cells in your skin and muscle that are exposed. Too much salt rather than a wash could lead to delayed healing.

 

Turmeric

Like salt water above, this can be applied to wounds on the skin rather than in the mouth for a similar effect. Just remember that turmeric stains are very hard to remove from either your clothes or skin before you start putting it all over yourself!

 

Oil of Oregano

Yes this was mentioned in the previous section but it works just as well on the skin as it does when ingested. It contains the strong chemical compounds of carvacrol and thymol that have powerful anti-bacterial and anti-fungal properties.

There are over 800 studies carried out looking into the effect of carvacrol which really backs up the anti-infective claims. It has proven effect as an anti-biotic, -fungal and -viral. It also can treat parasitic infection and reduce inflammation!

 

colloidal silver

Colloidal silver

This is a mixture of silver dust in distilled water and can be found in health stores as a dietary supplement. Another old remedy, this was used before the invention of antibiotics in 1938 by doctors around the world.

 

Fermented Foods

Pickles, Kim Chi (fermented korean cabbage) and sauerkraut all have antioxidants but more importantly antibiotics. These will help stave off infection in the gut.

 

echinacea

Echinacea

This is not an antibiotic but rather a personal antibiotic booster for your immune system, which means it can cut the duration of illness naturally. Used commonly around winter time to stave off seasonal infections.

 

Myrrh

Yes you read that right, the gift given at the birth of Jesus. Commiphora myrrha tree is the producer of an aromatic resin with multiple active ingredients. In the lab it has been seen fighting off multi-drug resistant bacteria that would otherwise survive treatment with hospital antibiotics.

Dr Shane Jackson

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About Shane Jackson (MBChB - Bachelor of Medicine, Bachelor of Surgery)

Shane Jackson (MBChB - Bachelor of Medicine, Bachelor of Surgery)
Shane is a medical doctor with over 8 years experience in both hospital medicine and surgery. He's completed over 2 years of surgical work focusing on trauma & orthopaedics alongside maxillofacial surgery. He has been involved in education since medical school and have written courses and taught classes. Having trained in Advanced Trauma and Life Support he is at the forefront of practical, out-of-hospital medicine which can be applied by the public to save lives.

5 comments

  1. How about mixing all the above items into a mush/paste, and maybe dry and capsulate. I dunno, just a thought. Or… buy all the above and take them everyday.

  2. Please, please remove the picture above Turmeric. That is a type of Echeveria, a succulent, nothing to do with turmeric which resembles a ginger and is indeed a member of the ginger family. I cringe when pictures of medicinal plants are mislabeled because, sure, someone will not do due research and use the wrong plant with possible dire consequences.

  3. Your article recommends drinking a tablespoon of apple cider vinegar. Never drink it straight, it can burn your throat and esophagus. Mix it in at least 8 oz. Or more of water.

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